Lateral gene transfer as a support for the tree of life. - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles Proceedings of the National Academy of Sciences of the United States of America Year : 2012

Lateral gene transfer as a support for the tree of life.

Abstract

Lateral gene transfer (LGT), the acquisition of genes from other species, is a major evolutionary force. However, its success as an adaptive process makes the reconstruction of the history of life an intricate puzzle: If no gene has remained unaffected during the course of life's evolution, how can one rely on molecular markers to reconstruct the relationships among species? Here, we take a completely different look at LGT and its impact for the reconstruction of the history of life. Rather than trying to remove the effect of LGT in phylogenies, and ignoring as a result most of the information of gene histories, we use an explicit phylogenetic model of gene transfer to reconcile gene histories with the tree of species. We studied 16 bacterial and archaeal phyla, representing a dataset of 12,000 gene families distributed in 336 genomes. Our results show that, in most phyla, LGT provides an abundant phylogenetic signal on the pattern of species diversification and that this signal is robust to the choice of gene families under study. We also find that LGT brings an abundant signal on the location of the root of species trees, which has been previously overlooked. Our results quantify the great variety of gene transfer rates among lineages of the tree of life and provide strong support for the "complexity hypothesis," which states that genes whose products participate to macromolecular protein complexes are relatively resistant to transfer.
Fichier principal
Vignette du fichier
2012_Abby_PNAS_1.pdf (2.25 Mo) Télécharger le fichier
Origin Publisher files allowed on an open archive
Loading...

Dates and versions

hal-00752055 , version 1 (29-05-2020)

Identifiers

Cite

Sophie S Abby, Eric Tannier, Manolo Gouy, Vincent Daubin. Lateral gene transfer as a support for the tree of life.. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (13), pp.4962-4967. ⟨10.1073/pnas.1116871109⟩. ⟨hal-00752055⟩
301 View
106 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More