Learning cell fate landscapes from spatial transcriptomics using Fused Gromov-Wasserstein
Abstract
Here, we propose STORIES, a method that employs an extension of Optimal Transport to learn a spatially informed potential. We benchmark our approach using three large Stereo-seq spatiotemporal atlases and demonstrate superior spatial coherence compared to existing approaches. Finally, we provide an in-depth analysis of axolotl neural regeneration and mouse gliogenesis, recovering gene trends for known markers as Nptx1 in neuron regeneration and Aldh1l1 in gliogenesis and additional putative drivers.
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Life Sciences [q-bio]Origin | Files produced by the author(s) |
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