Reconsidering the significance of genomic word frequencies. - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles Trends in Genetics Year : 2007

Reconsidering the significance of genomic word frequencies.


By conventional wisdom, a feature that occurs too often or too rarely in a genome can indicate a functional element. To infer functionality from frequency, it is crucial to precisely characterize occurrences in randomly evolving DNA. We find that the frequency of oligonucleotides in a genomic sequence follows primarily a Pareto-lognormal distribution, which encapsulates lognormal and power-law features found across all known genomes. Such a distribution could be the result of completely random evolution by a copying process. Our characterization of the entire frequency distribution of genomic words opens a way to a more accurate reasoning about their over- and underrepresentation in genomic sequences.

Dates and versions

inria-00448737 , version 1 (26-01-2010)



Miklós Csűrös, Laurent Noé, Gregory Kucherov. Reconsidering the significance of genomic word frequencies.. Trends in Genetics, 2007, 23 (11), pp.543-6. ⟨10.1016/j.tig.2007.07.008⟩. ⟨inria-00448737⟩
53 View
0 Download



Gmail Facebook X LinkedIn More