The industry requires innovative technologies to support the numeric design and simulation of manufactured products in order to reduce time to market delays and improve the performance of the products and the efficiency of the industries in the global competitive market. Innovation also requires advanced tools to support the design of new products. For example, remote teams are working collaboratively on the preliminary design of future aircraft that will be “safer, quieter, cleaner”, and environmentally friendly by 2020. The automotive industry has similar concerns. The telecom industries (e.g., mobile phones design) and nuclear power plant design face large-scale multi-physics simulation and optimization challenges. This paper suggests that distributed workflows running on computational grids are adequate to support their application needs.