Detection and Characterisation of Fibronectin Structures in the Tumour Extracellular Matrix* - Inria - Institut national de recherche en sciences et technologies du numérique
Communication Dans Un Congrès Année : 2024

Detection and Characterisation of Fibronectin Structures in the Tumour Extracellular Matrix*

Résumé

Characterising the tumour extracellular matrix (ECM) holds promise for identifying predictive biomarkers, particularly in assessing patient response to immunotherapy. While the cellular components of the tumour microenvironment have been extensively characterised, the non-cellular elements of this ecosystem remain underexplored. In this study, we investigated the geometry of Fibronectin (FN) in immunofluorescence images, a key ECM protein, in head and neck tumours. Our analysis identified two primary classes associated with FN structure: (a) aligned fibres, and (b) reticular fibre-like, which exist on a spectrum of structural variation. We proposed an approach leveraging Voronoi diagrams as adaptive windows. Circular statistics were then used to capture the spatial organisation of FN, providing insights into its structural heterogeneity within the tumour microenvironment.

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Dates et versions

hal-04738081 , version 1 (15-10-2024)

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  • HAL Id : hal-04738081 , version 1

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Faisal Jayousi, Xavier Descombes, Emmanuel Bouilhol, Anne Sudaka, Ellen van Obberghen-Schilling, et al.. Detection and Characterisation of Fibronectin Structures in the Tumour Extracellular Matrix*. EUSIPCO 2024, Aug 2024, Lyon, France. ⟨hal-04738081⟩
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