Operationalizing the centiloid scale for [18 F]florbetapir PET studies on PET/MRI
Résumé
INTRODUCTION
The Centiloid scale aims to harmonize amyloid beta (Aβ) positron emission tomography (PET) measures across different analysis methods. As Centiloids were created using PET/computerized tomography (CT) data and are influenced by scanner differences, we investigated the Centiloid transformation with data from Insight 46 acquired with PET/magnetic resonanceimaging (MRI).
METHODS
We transformed standardized uptake value ratios (SUVRs) from 432 florbetapir PET/MRI scans processed using whole cerebellum (WC) and white matter (WM) references, with and without partial volume correction. Gaussian-mixture-modelling–derived cutpoints for Aβ PET positivity were converted.
RESULTS
The Centiloid cutpoint was 14.2 for WC SUVRs. The relationship between WM and WC uptake differed between the calibration and testing datasets, producing implausibly low WM-based Centiloids. Linear adjustment produced a WM-based cutpoint of 18.1.
DISCUSSION
Transformation of PET/MRI florbetapir data to Centiloids is valid. However, further understanding of the effects of acquisition or biological factors on the transformation using a WM reference is needed.
HIGHLIGHTS
Centiloid conversion of amyloid beta positron emission tomography (PET) data aims to standardize results.
Centiloid values can be influenced by differences in acquisition.
We converted florbetapir PET/magnetic resonance imaging data from a large birth cohort.
Whole cerebellum referenced values could be reliably transformed to Centiloids.
White matter referenced values may be less generalizable between datasets.
Domaines
Imagerie médicale
Fichier principal
Alz Dem Diag Ass Dis Mo - 2023 - Coath - Operationalizing the centiloid scale for 18F florbetapir PET studies on PET.pdf (1.18 Mo)
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| Origine | Publication financée par une institution |
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