Synchronized MAC protocols are now considered as the ultimate solution to access the medium in wireless sensor networks. They guarantee both high throughout and constant latency and achieve reasonable energy consumption performance. However, synchronization is achieved at the cost of a complex framework with low flexibility on its parameters that is not suitable for some network topologies or application requirements. By contrast, asynchronous MAC protocols are versatile by nature but suffer from the tradeoff between energy consumption and latency. However, the addition of Wake-up Radio (WuR) can reduce the energy consumption of such protocols while maintaining very low latency thanks to its always-on feature and ultra-low power consumption. In this article, we present WuR- based Multi-hop Multi-channel (W2M), an asynchronous MAC protocol for wireless sensor networks. We also provide a fair comparison with Time Synchronized Channel Hopping (TSCH) through an extensive simulation campaign based on Contiki-NG and Cooja. Our results show that in low traffic scenarios, W2M outperforms TSCH in reducing both the energy consumption and the latency (at least 68% of energy is saved), but at the cost of slightly lower reliability.