The third hype of AI and enthusiasm for applying last techniques in all fields raise great interest and some important questions on the future directions in AI research and applications. Guiding by the principle of combing the best from human and computers capacities this chapter lists some important challenges to face and related directions in AI research. Multiple interrelated crises such as natural disasters, pandemics and other generated by humans require new approaches, combining existing techniques and set new directions for research. This chapter presents briefly the Artificial General Intelligence (AGI) concept and the challenges to face in sustainability, smart resources management, future connectivity, industry, agriculture, health, economy and education. The presented vision for the future of AI includes both researchers’ dreams and emergencies.