In a Collaborative Business Ecosystem, Performance Indicators are a useful mechanism to assess collaboration performance, inducing self-adjustment in organization’s profile, thereby improving the sustainability of the ecosystem. Using system dynamics and agent-based modelling, a simulation model is assembled to show organizations’ self-adjustment by improving their profile in response to an assessment through a chosen set of performance indicators, such as innovation indicator, contribution indicator and prestige indicator. The natural reaction of organizations (similar to individuals) towards improving their performance according to the way they are evaluated, is modelled considering different enterprise profiles categorized into various classes of responsiveness, to better simulate the diversity in a real collaborative business ecosystem. Preliminary results of this approach are presented and discussed.