In mature countries manufacturing is one of the most significant sources of economic development and growth. In those countries, manufacturing transformation systems will be grounded on seamless collaborative environments and will have a high degree of flexibility in production, in terms of product needs (specifications, quality, design), volume, timing, resource efficiency and cost, being able to adapt to customer needs and make use of the entire network chain for value creation. Future transformations systems will be massively collaborative and will be enabled by a network-centric approach, making use of multidimensional data analytics, driven by advanced ICT and the latest available proven manufacturing technologies.