As fog computing brings processing and storage resources to the edge of the network, there is an increasing need of automated placement (i.e., host selection) to deploy distributed applications. Such a placement must conform to applications’ resource requirements in a heterogeneous fog infrastructure, and deal with the complexity brought by Internet of Things (IoT) applications tied to sensors and actuators. This paper presents four heuristics to address the problem of placing distributed IoT applications in the fog. By combining proposed heuristics, our approach is able to deal with large scale problems, and to efficiently make placement decisions fitting the objective: minimizing placed applications’ average response time. The proposed approach is validated through comparative simulation of different heuristic combinations with varying sizes of infrastructures and applications.