PLM and Design Automation (DA) are two interdependent and necessary approaches to increase the performance and efficiency of product development processes. Often, DA systems’ usability suffers due to a lack of integration in industrial business environments stemming from the independent consideration of PLM and DA. This article proposes a methodological and modeling framework for developing and deploying DA solutions within a global PLM approach. This framework supports the identification of DA potentials and the definition of the DA task building blocks to support DA task formalization by practitioners. The aim is to make the specification and development of DA solutions more efficient and aligned with the business requirements and with the existing digital environments. This framework combines the usage of two standardized modeling languages to make the captured knowledge re-usable across heterogeneous PLM and DA applications. An industrial case study demonstrating the applicability of the framework is introduced and discussed.