The use of business games can help users to find solutions to complex management problems, to develop critical and strategic thinking skills, and to prepare professionals for the labor market. Business games as an active learning method has been widely debated, and there is a continuing interest in how students learn when they are stimulated. The goal of this research is to analyze the application of business games as an effective teaching methodology and decision-making in logistics processes in business administration undergraduate courses. The business game ENTERSIM was built with software and cloud computing. As the results, the student’s testimonies showed some deficiencies in the instructions given and in the activity application’s time. However, students emphasized the wish to carry out again activities that involve business games for bringing theory to practice. Students recognized the contribution of the business game to improve learning about operations, problem-solving, and decision-making.