This paper proposes a new Ant Colony Optimization (ACO)-inspired Information-Centric Networking (ICN) routing scheme with Density-based Spatial Clustering (DSC). At first, the content concentration model is established with network load to address interest routing; in particular, we investigate the failed situation of content retrieval. Then, the dot product method is used to compute similarity relation between two routers, which is considered as clustering reference attribute. In addition, DSC is exploited to detect core nodes which are used to cache contents during the data routing process. Finally, the proposed scheme is simulated over Mini-NDN, and the results show that it has better performance than the benchmark scheme.