Enterprise architecture-based approaches give an in-depth analytic potential for alignment and misalignment assessment. The ability to incorporate these analytic potentials is an ongoing concern in the state-of-the-art strategic alignment literature. This paper proposes a framework for EA artifact-based misalignment symptom detection. The framework aims to perform a systematic, EA-based analysis of mismatches between the business and IT dimensions of the traditional Strategic Alignment Model (SAM). By operating the framework, containing EA-artifacts and suitable EA analysis types are connected to typical misalignment symptoms along the traditional alignment perspectives. The operation of the framework is illustrated with a case study about a fleet management project at a road management authority.