Information Ecology represents a system of people, values, and technologies in a specific local environment. What makes Information Ecology different is that the spotlight is not on the technology but on human activities that are served by technology. As such it could be a powerful lens for understanding, evaluating, and eventually guiding South-South cooperation. We use Information Ecology to critically analyze two ICT-infused community health services, one in Bangladesh and one in Rwanda; and propose improvements for each case. Based on that analysis we believe that this framework can facilitate theoretical basis for guiding South-South cooperation, transferring knowledge and technology, and implementing policy recommendations.