A major challenge for the European industry is to enhance the productivity of software-intensive systems as well as to reduce their costs and increase their overall quality. Model-Driven Engineering (MDE) principles and techniques have already shown promising capabilities for software design, development, integration and maintenance. However, they still need to scale up to support real-world scenarios implied by the full deployment and use of complex cyber-physical systems (CPSs). In this context, maintaining efficient traceability, integration and communication between two fundamental system levels (i.e. design time and runtime) is an important challenge. This paper presents an overview of the set of tools and architectural approach envisioned by the H2020 ECSEL MegaM@Rt2 project (" MegaModelling at runtime – Scalable model-based framework for continuous development and runtime validation of complex systems "). The goal of this project is to address the above-mentioned challenges from a MDE perspective. Driven by both large and small industrial enterprises, with the support of research partners and technology providers, MegaM@Rt2 aims to deliver a framework of tools and approaches for: 1) system engineering/design & continuous development, 2) related runtime analysis and 3) global model & traceability management.