Information Science & Technology (IST) has pervasively affected our everyday life, thus becoming a proper cultural heritage of humanity. The growing curiosity about IST history has determined the creation of important collections devoted to the conservation of IST relics. Physical relics are naturally located close to their origins, but they are only one aspect of preservation and dissemination of IST history. The whole knowledge about IST history has to go beyond the local boundaries and become a globally shared and worldwide accessible heritage. Our proposal is to establish a Global Virtual Museum of IST based on a knowledge base able to manage all the information of the domain, created and updated by museum keepers and other experts, and capable of offering new enjoyment opportunities to a wider public audience. It is a radical change in the idea itself of cultural heritage information management, up to now bound to the traditional cataloguing approaches.