A rigorous evaluation of an artifact is one of the fundamental aspects to be considered in Design Science Research projects. This evaluation part becomes even more difficult when a large variety of artifacts must be designed for a project. This can be a challenge for the field of Collaborative Networks, which involves knowledge from several scientific disciplines. Case studies are one of the evaluation methods in Design Science Research that are used for an ex-post evaluation of artifacts. However, we argue that this method can also be used for the ex-ante evaluation, mainly when multidisciplinary research is being carried out. Therefore, the main objective of this paper is to present and discuss a multidisciplinary project of Collaborative Networks using case studies before and after the design of the artifacts. On top of the Design Science Research guidelines, this research is supported by knowledge from Business and Management Studies on how to effectively design and perform Case Study Research for artifact evaluation.