The synthesis of existing Persistent Organic Pollutants (POPs) pollution monitoring databases with epidemiological data is considered for identifying some impacts of POPs on human health. This task requires new, rich, data, services and models discovery capabilities from a multitude of monitoring networks and web resources. The FP7 project TaToo (Tagging Tool based on a Semantic Discovery Framework) is setting up a semantic web solution to close the discovery gap that prevents a full and easy access to web resources. The use of TaToo tools together with software GENASIS and SVOD is discussed as TaToo validation scenario for anthropogenic impact and global climate change influence on POPs trajectory. This paper contains the first propose of POPs and cancer domain ontology intended for TaToo framework.