The paper discussed the research course of the non-point source pollution and the application of spatial information technology to the non-point source pollution. Then we collected some spatial information data such as terrain, soil, water system, land use and so on, used MUSLE equation supported by geographic information system to get the risk distributing map of the non-point source pollution in Qingdao. The study met with good results. The result showed that the spatial information technology is a powerful tool to research the non-point source pollution and it can powerfully provide the decision support for management and control of the non-point source pollution.