The optimization of production logistics system is an important way to improve enterprise’s productivity, cut down cost and improve equipment’s utilization. Production logistics system is highly randomized, complicated and discrete system, which can hardly be modeled and analyzed in the traditional way, so computer simulation technology and eM-Plant simulation platform were introduced in the paper to model and analyze production logistics system, more than modeling eM-Plant also can analyze production logistics system’s equipment’s utilization, working efficiency, production capacity statistics effectively, which can offer useful guideline for production logistics system optimization and scientific decision-making.