Taking the molding block thickness, relaxation ratio and shatter resistance as evaluation indicators, the effects of compression parameters, which include mold form, compressive force, pressure-holding time and loading rate, on molding block quality of fish floss were investigated by means of single factor and orthogonal test. The results showed that: 1) the mold form, compressive force, pressure-holding time and loading rate have great impact on the molding block thickness, and the block thickness decreases with the increase of compressive force and pressure-holding time; 2) the loading rate and pressure-holding time affect the relaxation ratio of molding block significantly; 3) the pressure-holding time highly affects the shatter resistance of molding block, and the shatter resistance will be greatly improved after a period of pressure holding;4) the interactions between different parameters have no significant effect on the molding block quality. The results can provide references for the development of compression molding equipment and selection of the technique parameters.