Using mobile devices enhances overall collaboration and communication between team workers. Co-workers can collaborate and share content regardless of their location. Workflow management is a widely accepted technology that supports collaboration; however, existing workflow approaches provide only a limited support for content management. Moreover, constantly changing collaborators’ contexts and needs demand more adaptable and flexible workflows. The aim of this paper is to examine how collaborative workflows can be adapted for mobile devices, be capable of dealing with current collaborators’ context and support content manipulation. As a result, a conceptual reference framework for the definition, management and execution of mobile context-aware content-centric workflows is introduced.