Enterprise Information Systems (EIS) can be classified into three generations, starting with the application-centric, moving on to the data-centric and then to contemporary thinking, which can be described as process-centric. The overall theme of CONFENIS 2011 was to re-conceptualize EIS. One way of re-conceptualizing is to start with a blank sheet and “think out of the box”. This topic was addressed in a workshop at CONFENIS 2011 which focused on the future of EIS. The workshop consisted of a large number of experts from across the world, divided into seven groups, who discussed the topic using LEGO SERIOUS PLAY to facilitate and stimulate the discussions. The group of seven came up with seven challenges for the future of EIS and we propose that the next generation of EIS should be conceptualized as human-centric.