In this article we discuss the route planning of Hazardous Materials (HAZMAT). For HAZMAT transportation, safety and security is of utmost importance. Because of this, the route planning needs to consider potential risks and costs to find an optimal route for the transportation. It has been shown that the route planning is an NP hard problem. In this article, we approach the problem from a novel point of the view. As the main contribution, we present in this article a GIS-based route planing method that has many complementary advantages to graph-based route planning methods. We also illustrate the use of the method with a simple case study.