New approaches and technologies like Internet of Things (IoT), cloud computing and Big Data are giving rise to another industrial revolution. We propose here an implementation of an industrial gateway architecture adopting the idea of IoT, intelligent methods, Machine-to-Machine and Cyber-Physical Systems. The proposed gateway creates a virtual representation of the physical world scanning the technological layer’s devices in real time. It creates a uniform communication interface for the heterogeneous technological layer, enables self-management of devices, diagnostics and self-reconfiguration to improve Quality of Service aided with cloud SCADA and MES services. We have tested the proposed gateway in an experimental setup with a programmable logic controller.