Design science has been used as a new research paradigm in information quality research. Within design science, experimental validation has been recognized as one of the most important research methodologies. However, as there is a lack of a coherent framework for conducting experimental research, different information quality studies may produce different results, which can be even conflicting. In order to reduce this ambiguity, we have proposed a framework that is used to (1) refine the experimental methodology in information quality research, (2) advance the rigorous information quality research in design science, and (3) demonstrate an exemplary experimental validation in design science.