Using a network to manage enterprise office affairs is an important means of improving efficiency of the office management and achieving standardization for the enterprise business. The major technology about using PHP and MySQL to develop an enterprise office management system was illustrated in this paper. The contents including the realization of functional modules were discussed, such as: The foreground web page module used by employees, business management module, design of the database tables and web management technology of administrator. The system has features of full-featured, high-efficiency, advanced technology. The systems provide an important reference platform to help enterprise reduce management costs, improve internal management, and enhance competition in the market for comprehensive competitiveness.