—Low-power wireless devices suffer notoriously from Cross-Technology Interference (CTI). To enable coexistence , researchers have proposed a variety of interference mitigation strategies. Existing solutions, however, are designed to work with the limitations of currently available radio chips. In this paper, we investigate how to exploit physical layer properties of 802.15.4 signals to better address CTI. We present CrossZig, a cross-layer solution that takes advantage of physical layer information and processing to improve low-power communication under CTI. To this end, CrossZig utilizes physical layer information to detect presence of CTI in a corrupted packet and to apply an adaptive packet recovery which incorporates a novel cross-layer based packet merging and an adaptive FEC coding. We implement a prototype of CrossZig for the low-power IEEE 802.15.4 in a software-defined radio platform. We show the adaptability and the performance gain of CrossZig through experimental evaluation considering both micro-benchmarking and system performance under various interference patterns. Our results demonstrate that CrossZig can achieve a high accuracy in error localization (94.3% accuracy) and interference type identification (less than 5% error rate for SINR ranges below 3 dB). Moreover, our system shows consistent performance improvements under interference from various interfering technologies.