There is an emerging research area to adopt bio-inspired algorithms to self-organize an information network system. Despite strong interests on their benefits, i.e. high robustness, adaptability, and scalability, the behavior of bio-inspired algorithms under non-negligible perturbation such as loss of information and failure of nodes observed in the realistic environment is not well investigated. Because of lack of knowledge, none can clearly identify the range of application of a bio-inspired algorithm to challenging issues of information networks. Therefore, to tackle the problem and accelerate researches in this area, we need to understand characteristics of bio-inspired algorithms from the perspective of network control. In this paper, taking a response threshold model as an example, we discuss the robustness and adaptability of bio-inspired model and its application to network control. Through simulation experiments and mathematical analysis, we show an existence condition of the equilibrium state in the lossy environment. We also clarify the influence of the environmental condition and control parameters on the transient behavior and the recovery time.