Equilibria and stability analysis of a branched metabolic network with feedback inhibition - Inria - Institut national de recherche en sciences et technologies du numérique
Communication Dans Un Congrès Année : 2004

Equilibria and stability analysis of a branched metabolic network with feedback inhibition

Résumé

This paper deals with the analysis of a metabolic network with feedback inhibition. The considered system is an acyclic network of mono-molecular enzymatic reactions in which metabolites can act as feedback regulators on "preceding" enzymes of their own pathway, and in which one metabolite is the root of the whole network. We show, under mild assumptions, the uniqueness of the equilibrium. In the simplified case where inhibition only acts on the reactions having the root of the network as substrate, we show that the equilibrium is globally attractive. This requires that we impose conditions on the kinetic parameters of the metabolic reactions.
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Dates et versions

hal-01091728 , version 1 (05-12-2014)

Identifiants

  • HAL Id : hal-01091728 , version 1

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Frédéric Grognard, Yacine Chitour, Georges Bastin. Equilibria and stability analysis of a branched metabolic network with feedback inhibition. 9th International Symposium on Computer Applications in Biotechnology, Mar 2004, Nancy, France. ⟨hal-01091728⟩
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