Full-Duplex radio provides many benefits beyond improving spectral efficiency. However, canceling the self-interference completely is a big challenge behind Full-Duplex wireless. Although many intelligent efforts devote to active analog radio frequency self-interference cancellation (AARFSIC), the power of the residual self-interference (SI) after the AARFSIC is still much stronger than that of the receiver thermal noise. In this paper, we first study deeply the AARFSIC and "dig" the core problem that causing the residual SI, and then propose a digital self-interference cancellation in time domain (DSICT) to complement AARFSIC for the Full-Duplex OFDM wireless. The ADS-Matlab co-simulation results demonstrate the actual performance and show that the residual SI after the AARFSIC can be canceled completely by employing the proposed DSICT.