This paper deals with the use of non destructive testing methods (NDT) to assess indicators of concrete durability and mechanical properties of reinforced concrete structures. On site, NDT methods based on electromagnetic or ultrasonic wave propagation (such as radar, impact echo, ultrasonic transmission deviceÉ) are used because they are more or less sensitive to water content and mechanical properties depending on the method. It has been shown, in a former project [1, 2], that the NDT results called Òobservablesî are linked to mechanical and durability indicators (YoungÕs modulus, compressive strength, porosity and saturation degree). Meanwhile, the relationship between observables and indicators depends on the concrete mix design. A calibration protocol is then proposed to get this relationship for the right mix of the reinforced structure studied by using a minimal number of cores. The cores are non-destructively characterised in laboratory or used to determined reference indicators by standardised destructive methods. The aims of this paper are first to present the ND calibration protocol on cores and then to validate this proposed calibration protocol. To achieve this goal, some NDT results obtained on site and on the corresponding core are compared and durability indicators deduced from NDT calibration are compared with reference durability indicators.