In his comment in this issue of the Biophysical Journal, V.P. Shkilev (1) disagrees with some of the findings of our article on the influence of diffusion on the ligand-binding equilibrium (2). V.P. Shkilev makes two main claims in his comment: (i) when diffusion is uniformly Brownian (with a space-independent diffusion coefficient), "the equilibrium fraction of bound receptors [...] should depend on the dif- fusion coefficient" and (ii) when molecules undergo tran- sient subdiffusion due to a Continuous-Time Random Walk (CTRW), the equilibrium fraction of bound receptors can only be equal or larger (but not smaller) than the value ex- pected for uniform Brownian motion with comparable dif- fusion coefficient. While the former is a frequent miscon- ception related to the ligand-binding equilibrium, the lat- ter relates to an important issue in the field of (anomalous) subdiffusion-reaction couplings.