Genomic regions harboring insecticide resistance-associated Cyp genes are enriched by transposable element fragments carrying putative transcription factor binding sites in two sibling Drosophila species - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles Gene Year : 2014

Genomic regions harboring insecticide resistance-associated Cyp genes are enriched by transposable element fragments carrying putative transcription factor binding sites in two sibling Drosophila species

Abstract

In the present study, an in silico analysis was performed to identify transposable element (TE) fragments inserted in Cyps with functions associated with resistance to insecticides and developmental regulation as well as in neighboring genes in two sibling species, Drosophila melanogaster and Drosophila simulans. The Cyps associated with insecticide resistance and their neighboring non-Cyp genes have accumulated a greater number of TE fragments than the other Cyps or a random sample of genes, predominantly in the 5'-flanking regions. Most of the insertions were due to DNA transposons, with DNAREP1 fragments being the most common. These fragments carry putative binding sites for transcription factors, which reinforces the hypothesis that DNAREP1 may influence gene regulation and play a role in the adaptation of the Drosophila species.
Fichier principal
Vignette du fichier
carareto2014.pdf (608.53 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-00922703 , version 1 (04-07-2017)

Identifiers

Cite

Claudia M A Carareto, Eric H Hernandez, Cristina Vieira. Genomic regions harboring insecticide resistance-associated Cyp genes are enriched by transposable element fragments carrying putative transcription factor binding sites in two sibling Drosophila species. Gene, 2014, 537 (1), pp.93-99. ⟨10.1016/j.gene.2013.11.080⟩. ⟨hal-00922703⟩
218 View
413 Download

Altmetric

Share

Gmail Facebook X LinkedIn More