As a direct consequence of the increasing popularity of Cloud Computing solutions, data centers are amazingly growing and hence have to urgently face with the energy consumption issue. Available solutions rely on Cloud Computing models and virtualization techniques to scale up/down application based on their performance metrics. Although those proposals can reduce the energy footprint of applications and by transitivity of cloud infrastructures, they do not consider the internal characteristics of applications to finely define a trade-off between applications Quality of Service and energy footprint. In this paper, we propose a self-adaptation approach that considers both application internals and system to reduce the energy footprint in cloud infrastructure. Each application and the infrastructure are equipped with their own control loop, which allows them to autonomously optimize their executions. Simulations show that the approach may lead to appreciable energy savings without interfering on application provider revenues.