Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe. - Institut Pasteur de la Guadeloupe Accéder directement au contenu
Article Dans Une Revue FEMS Immunology and Medical Microbiology Année : 1998

Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.

Résumé

Eight chemically defined, naturally occurring compounds were extracted from the tropical flora of the Caribbean island of Guadeloupe: pilocarpine, an alkaloid from Pilocarpus racemosus; heraclenol and isomeranzin, coumarins from Triphasia trifolia; lochnerin, an indole alkaloid from Rauwolfia biauriculata; ibogaine and voacangine, indole alkaloids from Tabernaemontana citrifolia; texalin, an oxazole from Amyris elemifera; and canellal, a sesquiterpene dialdehyde from Canella winterana. An essential oil fraction from Canella winterana was also tested. The antimycobacterial activity of these substances was tested against Mycobacterium tuberculosis, M. avium and M. kansasii using the Middlebrook 7H11 agar medium, the Bactec 460-TB radiometric methodology, and determination of bacterial viable counts. Three compounds, namely ibogaine, voacangine and texalin, showed antimycobacterial activity. Investigations on the structure-modification and structure-activity relationships of these compounds may help determine new targets for future drug development.

Domaines

Bactériologie

Dates et versions

pasteur-00931155 , version 1 (15-01-2014)

Identifiants

Citer

N. Rastogi, J. Abaul, K. S. Goh, A. Devallois, E. Philogène, et al.. Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.. FEMS Immunology and Medical Microbiology, 1998, 20 (4), pp.267-273. ⟨10.1111/j.1574-695X.1998.tb01136.x⟩. ⟨pasteur-00931155⟩
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