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Article Dans Une Revue Archives of cardiovascular diseases Année : 2021

Characteristics and impact of cardiovascular comorbidities on coronavirus disease 2019 in women: A multicentre cohort study

Orianne Weizman
Joffrey Cellier
Laura Geneste
  • Fonction : Auteur
Antonin Trimaille
Thibaut Pommier
Vassili Panagides
Wassima Marsou
  • Fonction : Auteur
Antoine Deney
  • Fonction : Auteur
Sabir Attou
  • Fonction : Auteur
Thomas Delmotte
  • Fonction : Auteur
Sophie Ribeyrolles
  • Fonction : Auteur
Pascale Chemaly
Clément Karsenty
  • Fonction : Auteur
Gauthier Giordano
  • Fonction : Auteur
Alexandre Gautier
Corentin Chaumont
Pierre Guilleminot
  • Fonction : Auteur
Audrey Sagnard
  • Fonction : Auteur
Julie Pastier
  • Fonction : Auteur
Baptiste Duceau
  • Fonction : Auteur
Willy Sutter
Charles Fauvel
Théo Pezel
  • Fonction : Auteur
Guillaume Bonnet
  • Fonction : Auteur
Ariel Cohen
  • Fonction : Auteur
Victor Waldmann
  • Fonction : Auteur

Résumé

Background: Although women account for up to half of patients hospitalized for coronavirus disease 2019 (COVID-19), no specific data have been reported in this population.Aims: To assess the burden and impact of cardiovascular comorbidities in women with COVID-19.Methods: All consecutive patients hospitalized for COVID-19 across 24 hospitals from 26 February to 20 April 2020 were included. The primary composite outcome was transfer to an intensive care unit or in-hospital death.Results: Among 2878 patients, 1212 (42.1%) were women. Women were older (68.3±18.0 vs. 65.4±16.0 years; P<0.001), but had less prevalent cardiovascular comorbidities than men. Among women, 276 (22.8%) experienced the primary outcome, including 161 (13.3%) transfers to an intensive care unit and 115 (9.5%) deaths without transfer to intensive care unit. The rate of in-hospital death or transfer to an intensive care unit was lower in women versus men (crude hazard ratio [HR]: 0.62, 95% confidence interval [CI]: 0.53-0.72). Age (adjusted HR: 1.05 per 5-year increase, 95% CI: 1.01-1.10), body mass index (adjusted HR: 1.06 per 2-unit increase, 95% CI: 1.02-1.10), chronic kidney disease (adjusted HR: 1.57, 95% CI: 1.11-2.22) and heart failure (adjusted HR: 1.52, 95% CI: 1.04-2.22) were independently associated with the primary outcome in women. Elevated B-type natriuretic peptide/N-terminal prohormone of B-type natriuretic peptide (adjusted HR: 2.41, 95% CI: 1.70-3.44) and troponin (adjusted HR: 2.00, 95% CI: 1.39-2.88) concentrations at admission were also associated with the primary outcome, even in women free of previous coronary artery disease or heart failure.Conclusions: Although female sex was associated with a lower risk of transfer to an intensive care unit or in-hospital death, COVID-19 remained associated with considerable morbimortality in women, especially in those with cardiovascular diseases.
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hal-04433185 , version 1 (22-07-2024)

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Orianne Weizman, Delphine Mika, Joffrey Cellier, Laura Geneste, Antonin Trimaille, et al.. Characteristics and impact of cardiovascular comorbidities on coronavirus disease 2019 in women: A multicentre cohort study. Archives of cardiovascular diseases, 2021, 114 (5), pp.394-406. ⟨10.1016/j.acvd.2021.04.002⟩. ⟨hal-04433185⟩
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