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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Patricio Godoy
,
Nicola J Hewitt
,
Ute Albrecht
,
Melvin E Andersen
,
Nariman Ansari
et al.
Journal articles
hal-00939009v1
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Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response
Estefanie Dufey
,
José Manuel Bravo-San Pedro
,
Cristian Eggers
,
Matías González-Quiroz
,
Hery Urra
et al.
Journal articles
hal-02862260v1
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Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1 alpha
Denisse Sepulveda
,
Diego Rojas-Rivera
,
Diego A. Rodriguez
,
Jody Groenendyk
,
Andres Kohler
et al.
Journal articles
hal-01710048v1
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Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood
Ahmed Ghallab
,
Ute Hofmann
,
Selahaddin Sezgin
,
Nachiket Vartak
,
Reham Hassan
et al.
Journal articles
hal-02425193v2
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Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases
Ahmed Ghallab
,
Geraldine Celliere
,
Sebastian Henkel
,
Dominik Driesch
,
Stefan Hoehme
et al.
Journal articles
hal-01257127v1
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The virtual liver: state of the art and future perspectives
Dirk Drasdo
,
Johannes Bode
,
Uta Dahmen
,
Olaf Dirsch
,
Steven Dooley
et al.
Journal articles
hal-01110684v1
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Adverse outcome pathways: opportunities, limitations and open questions
Marcel Leist
,
Ahmed Ghallab
,
Rabea Graepel
,
Rosemarie Marchan
,
Reham Hassan
et al.
Journal articles
hal-01968849v1
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Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis.
Seddik Hammad
,
Stefan Hoehme
,
Adrian Friebel
,
Iris von Recklinghausen
,
Amnah Othman
et al.
Journal articles
hal-01110657v1
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