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authFullName_s : Patricio Godoy

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Patricio Godoy , Nicola J Hewitt , Ute Albrecht , Melvin E Andersen , Nariman Ansari et al.
Archives of Toxicology, 2013, 87 (8), pp.1315-530. ⟨10.1007/s00204-013-1078-5⟩
Journal articles hal-00939009v1
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Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response

Estefanie Dufey , José Manuel Bravo-San Pedro , Cristian Eggers , Matías González-Quiroz , Hery Urra et al.
Nature Communications, 2020, 11 (1), pp.2401. ⟨10.1038/s41467-020-15694-y⟩
Journal articles hal-02862260v1

Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1 alpha

Denisse Sepulveda , Diego Rojas-Rivera , Diego A. Rodriguez , Jody Groenendyk , Andres Kohler et al.
Molecular Cell, 2018, 69 (2), pp.238-252.e7. ⟨10.1016/j.molcel.2017.12.028⟩
Journal articles hal-01710048v1

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood

Ahmed Ghallab , Ute Hofmann , Selahaddin Sezgin , Nachiket Vartak , Reham Hassan et al.
Hepatology, 2019, 69 (2), pp.666-683. ⟨10.1002/hep.30213⟩
Journal articles hal-02425193v2
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Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases

Ahmed Ghallab , Geraldine Celliere , Sebastian Henkel , Dominik Driesch , Stefan Hoehme et al.
Journal of Hepatology, 2015, 64 (4), pp.860-871. ⟨10.1016/j.jhep.2015.11.018⟩
Journal articles hal-01257127v1

The virtual liver: state of the art and future perspectives

Dirk Drasdo , Johannes Bode , Uta Dahmen , Olaf Dirsch , Steven Dooley et al.
Archives of Toxicology, 2014, pp.2071-2075. ⟨10.1007/s00204-014-1384-6⟩
Journal articles hal-01110684v1

Adverse outcome pathways: opportunities, limitations and open questions

Marcel Leist , Ahmed Ghallab , Rabea Graepel , Rosemarie Marchan , Reham Hassan et al.
Archives of Toxicology, 2017, 91 (11), pp.3477-3505. ⟨10.1007/s00204-017-2045-3⟩
Journal articles hal-01968849v1

Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis.

Seddik Hammad , Stefan Hoehme , Adrian Friebel , Iris von Recklinghausen , Amnah Othman et al.
Archives of Toxicology, 2014, 88 (5), pp.1161-1183. ⟨10.1007/s00204-014-1243-5⟩
Journal articles hal-01110657v1