TP53 codon 72 polymorphism, p53 expression, and 1p/19q status in oligodendroglial tumors. - Inria - Institut national de recherche en sciences et technologies du numérique Accéder directement au contenu
Article Dans Une Revue Cancer Genetics and Cytogenetics Année : 2007

TP53 codon 72 polymorphism, p53 expression, and 1p/19q status in oligodendroglial tumors.

Résumé

The functional single-nucleotide polymorphism (SNP) in codon 72 of TP53 has been shown to be both a risk factor and a prognostic biomarker in various cancers. Such results were also reported in brain tumors, notably in astrocytomas. This SNP has never been precisely investigated in oligodendroglial tumors. We retrospectively analyzed blood samples of 275 oligodendroglial tumor patients for the TP53 codon 72 polymorphism and compared them with a series of 144 healthy controls. Arg/Arg, Arg/Pro, and Pro/Pro genotypes were found in 54.2 versus 60.4%, 39.3 versus 34.0%, and 7.3 versus 5.6% of patients and controls, respectively. This suggests no association between oligodendroglial tumors and the SNP in codon 72 of TP53. Similarly, no correlation was found among the TP53 codon 72 polymorphism and prognosis, p53 expression, and chromosomes 1p and 19q status.

Dates et versions

inserm-00310509 , version 1 (10-08-2008)

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Citer

Ahmed Idbaih, Blandine Boisselier, Yannick Marie, Soufiane El Hallani, Marc Sanson, et al.. TP53 codon 72 polymorphism, p53 expression, and 1p/19q status in oligodendroglial tumors.. Cancer Genetics and Cytogenetics, 2007, 177 (2), pp.103-7. ⟨10.1016/j.cancergencyto.2007.06.010⟩. ⟨inserm-00310509⟩
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