Multi-Atlas Tensor-Based Morphometry and its Application to a Genetic Study of 92 Twins - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Conference Papers Year : 2008

Multi-Atlas Tensor-Based Morphometry and its Application to a Genetic Study of 92 Twins

Abstract

Here we develop a multi-template analysis for tensor-based morphometry (TBM) which aims to reduce error from the registration step. In conventional TBM, a single template is nonlinearly registered to all images in the study, and the deformation field statistics are computed from the transformations. Using an MRI dataset from 23 monozygotic and 23 dizygotic twin pairs, we instead registered each individual twin image to 9 additional brain templates using a Riemannian fluid algo- rithm [3]. Average deformation tensors from multiple registrations were computed within each image, using a log-Euclidean framework [1]. To quantify improvements as the number of registration templates increased from 1 to 9, sequential t-tests assessed the significance of any error re- duction, as each new template was added. For each number of templates, we also computed two tensor-derived metrics, and maps of the intraclass correlation of local volume differences, to evaluate any power advantages of multi-atlas TBM.

Domains

Other [cs.OH]
Fichier principal
Vignette du fichier
mfca08_2_2.pdf (120.28 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

inria-00632873 , version 1 (16-10-2011)

Identifiers

  • HAL Id : inria-00632873 , version 1

Cite

Natasha Leporé, Caroline Brun, Yi-Yu Chou, Agatha Lee, Marina Barysheva, et al.. Multi-Atlas Tensor-Based Morphometry and its Application to a Genetic Study of 92 Twins. 2nd MICCAI Workshop on Mathematical Foundations of Computational Anatomy, Oct 2008, New-York, United States. pp.48-55. ⟨inria-00632873⟩

Collections

MFCA MFCA08
489 View
177 Download

Share

Gmail Facebook Twitter LinkedIn More