<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-05238567v1</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-25T04:36:01+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">The SChISM study: Cell-free DNA size profiles as predictors of progression in advanced carcinoma treated with immune-checkpoint inhibitors</title>
            <author role="aut">
              <persName>
                <forename type="first">Linh</forename>
                <surname>Nguyen Phuong</surname>
              </persName>
              <email type="md5">73dd04fe6fa115c142752e80ca9bfa66</email>
              <email type="domain">inria.fr</email>
              <idno type="idhal" notation="numeric">1357964</idno>
              <idno type="halauthorid" notation="string">3012358-1357964</idno>
              <affiliation ref="#struct-1071285"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Frederic</forename>
                <surname>Fina</surname>
              </persName>
              <email type="md5">0bb9142b902b551625ee18e12f144b59</email>
              <email type="domain">ap-hm.fr</email>
              <idno type="idhal" notation="numeric">1002614</idno>
              <idno type="halauthorid" notation="string">851820-1002614</idno>
              <affiliation ref="#struct-1525607"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laurent</forename>
                <surname>Greillier</surname>
              </persName>
              <email type="md5">69e0604f00b9e00e17d404bc17e2d066</email>
              <email type="domain">ap-hm.fr</email>
              <idno type="idhal" notation="numeric">777166</idno>
              <idno type="halauthorid" notation="string">1003929-777166</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5807-9503</idno>
              <idno type="IDREF">https://www.idref.fr/116390867</idno>
              <idno type="VIAF">https://viaf.org/viaf/107060187</idno>
              <affiliation ref="#struct-1071285"/>
              <affiliation ref="#struct-300073"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pascale</forename>
                <surname>Tomasini</surname>
              </persName>
              <email type="md5">50da72592ae7811c542c1382cf56a4cd</email>
              <email type="domain">ap-hm.fr</email>
              <idno type="idhal" notation="numeric">1120220</idno>
              <idno type="halauthorid" notation="string">1139793-1120220</idno>
              <affiliation ref="#struct-300073"/>
              <affiliation ref="#struct-1071285"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Laurent</forename>
                <surname>Deville</surname>
              </persName>
              <idno type="idhal" notation="numeric">813355</idno>
              <idno type="halauthorid" notation="string">2327911-813355</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9727-5710</idno>
              <affiliation ref="#struct-300093"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Romain</forename>
                <surname>Zakrasjek</surname>
              </persName>
              <idno type="halauthorid">3752139-0</idno>
              <affiliation ref="#struct-1071285"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lucie</forename>
                <surname>Della-Negra</surname>
              </persName>
              <idno type="halauthorid">3752140-0</idno>
              <affiliation ref="#struct-1071285"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Audrey</forename>
                <surname>Boutonnet</surname>
              </persName>
              <idno type="halauthorid">1021886-0</idno>
              <affiliation ref="#struct-573134"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Frédéric</forename>
                <surname>Ginot</surname>
              </persName>
              <email type="md5">e1fbe1e56dd6429cb6a020ac4cc4374b</email>
              <email type="domain">adelis-tech.com</email>
              <idno type="idhal" notation="numeric">1441330</idno>
              <idno type="halauthorid" notation="string">964258-1441330</idno>
              <affiliation ref="#struct-573134"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Charles</forename>
                <surname>Garcia</surname>
              </persName>
              <idno type="halauthorid">3012359-0</idno>
              <affiliation ref="#struct-573134"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sébastien</forename>
                <surname>Benzekry</surname>
              </persName>
              <email type="md5">058c3fc27bb7f758cba0c0195d61a833</email>
              <email type="domain">phare.normalesup.org</email>
              <idno type="idhal" notation="string">sebastien-benzekry</idno>
              <idno type="idhal" notation="numeric">12116</idno>
              <idno type="halauthorid" notation="string">9370-12116</idno>
              <idno type="ARXIV">https://arxiv.org/a/benzekry_s_1</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3749-8637</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=xsLpdFAAAAAJ&amp;hl=fr&amp;oi=ao</idno>
              <idno type="IDREF">https://www.idref.fr/159344212</idno>
              <affiliation ref="#struct-1071285"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sébastien</forename>
                <surname>Salas</surname>
              </persName>
              <idno type="idhal" notation="numeric">1196409</idno>
              <idno type="halauthorid" notation="string">1201526-1196409</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6222-5027</idno>
              <affiliation ref="#struct-1071285"/>
              <affiliation ref="#struct-300093"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Sebastien</forename>
                <surname>Benzekry</surname>
              </persName>
              <email type="md5">6265406c2f4b74e0106bf0ba27675c40</email>
              <email type="domain">inria.fr</email>
            </editor>
            <funder>This work received support from the French government under the France 2030 investment plan, as part of the Initiative d’Excellence d’Aix-Marseille Université–A*MIDEX (AMX-19-IET-001 &amp; AMX-21-IET-017).</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-09-03 16:53:20</date>
              <date type="whenModified">2026-01-21 03:15:48</date>
              <date type="whenReleased">2025-09-05 11:02:04</date>
              <date type="whenProduced">2025-09-03</date>
              <date type="whenEndEmbargoed">2025-09-03</date>
              <ref type="file" target="https://inria.hal.science/hal-05238567v1/document">
                <date notBefore="2025-09-03"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://inria.hal.science/hal-05238567v1/file/manuscript_results_baseline.pdf" id="file-5238567-4502906">
                <date notBefore="2025-09-03"/>
              </ref>
              <ref type="externalLink" target="http://arxiv.org/pdf/2509.04939"/>
            </edition>
            <edition n="v2">
              <date type="whenSubmitted">2026-01-20 10:23:40</date>
            </edition>
            <edition n="v3">
              <date type="whenSubmitted">2026-02-02 14:30:21</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="153845">
                <persName>
                  <forename>Sebastien</forename>
                  <surname>Benzekry</surname>
                </persName>
                <email type="md5">6265406c2f4b74e0106bf0ba27675c40</email>
                <email type="domain">inria.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-05238567</idno>
            <idno type="halUri">https://inria.hal.science/hal-05238567</idno>
            <idno type="halBibtex">nguyenphuong:hal-05238567</idno>
            <idno type="halRefHtml">2025</idno>
            <idno type="halRef">2025</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-5238567-4502906"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="LAENNEC">Institut Laënnec - Sciences Numériques et IA pour la santé</idno>
          </seriesStmt>
          <notesStmt/>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">The SChISM study: Cell-free DNA size profiles as predictors of progression in advanced carcinoma treated with immune-checkpoint inhibitors</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Linh</forename>
                    <surname>Nguyen Phuong</surname>
                  </persName>
                  <email type="md5">73dd04fe6fa115c142752e80ca9bfa66</email>
                  <email type="domain">inria.fr</email>
                  <idno type="idhal" notation="numeric">1357964</idno>
                  <idno type="halauthorid" notation="string">3012358-1357964</idno>
                  <affiliation ref="#struct-1071285"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Frederic</forename>
                    <surname>Fina</surname>
                  </persName>
                  <email type="md5">0bb9142b902b551625ee18e12f144b59</email>
                  <email type="domain">ap-hm.fr</email>
                  <idno type="idhal" notation="numeric">1002614</idno>
                  <idno type="halauthorid" notation="string">851820-1002614</idno>
                  <affiliation ref="#struct-1525607"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laurent</forename>
                    <surname>Greillier</surname>
                  </persName>
                  <email type="md5">69e0604f00b9e00e17d404bc17e2d066</email>
                  <email type="domain">ap-hm.fr</email>
                  <idno type="idhal" notation="numeric">777166</idno>
                  <idno type="halauthorid" notation="string">1003929-777166</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5807-9503</idno>
                  <idno type="IDREF">https://www.idref.fr/116390867</idno>
                  <idno type="VIAF">https://viaf.org/viaf/107060187</idno>
                  <affiliation ref="#struct-1071285"/>
                  <affiliation ref="#struct-300073"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pascale</forename>
                    <surname>Tomasini</surname>
                  </persName>
                  <email type="md5">50da72592ae7811c542c1382cf56a4cd</email>
                  <email type="domain">ap-hm.fr</email>
                  <idno type="idhal" notation="numeric">1120220</idno>
                  <idno type="halauthorid" notation="string">1139793-1120220</idno>
                  <affiliation ref="#struct-300073"/>
                  <affiliation ref="#struct-1071285"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Laurent</forename>
                    <surname>Deville</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">813355</idno>
                  <idno type="halauthorid" notation="string">2327911-813355</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9727-5710</idno>
                  <affiliation ref="#struct-300093"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Romain</forename>
                    <surname>Zakrasjek</surname>
                  </persName>
                  <idno type="halauthorid">3752139-0</idno>
                  <affiliation ref="#struct-1071285"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lucie</forename>
                    <surname>Della-Negra</surname>
                  </persName>
                  <idno type="halauthorid">3752140-0</idno>
                  <affiliation ref="#struct-1071285"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Audrey</forename>
                    <surname>Boutonnet</surname>
                  </persName>
                  <idno type="halauthorid">1021886-0</idno>
                  <affiliation ref="#struct-573134"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Frédéric</forename>
                    <surname>Ginot</surname>
                  </persName>
                  <email type="md5">e1fbe1e56dd6429cb6a020ac4cc4374b</email>
                  <email type="domain">adelis-tech.com</email>
                  <idno type="idhal" notation="numeric">1441330</idno>
                  <idno type="halauthorid" notation="string">964258-1441330</idno>
                  <affiliation ref="#struct-573134"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Charles</forename>
                    <surname>Garcia</surname>
                  </persName>
                  <idno type="halauthorid">3012359-0</idno>
                  <affiliation ref="#struct-573134"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sébastien</forename>
                    <surname>Benzekry</surname>
                  </persName>
                  <email type="md5">058c3fc27bb7f758cba0c0195d61a833</email>
                  <email type="domain">phare.normalesup.org</email>
                  <idno type="idhal" notation="string">sebastien-benzekry</idno>
                  <idno type="idhal" notation="numeric">12116</idno>
                  <idno type="halauthorid" notation="string">9370-12116</idno>
                  <idno type="ARXIV">https://arxiv.org/a/benzekry_s_1</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3749-8637</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=xsLpdFAAAAAJ&amp;hl=fr&amp;oi=ao</idno>
                  <idno type="IDREF">https://www.idref.fr/159344212</idno>
                  <affiliation ref="#struct-1071285"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sébastien</forename>
                    <surname>Salas</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1196409</idno>
                  <idno type="halauthorid" notation="string">1201526-1196409</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6222-5027</idno>
                  <affiliation ref="#struct-1071285"/>
                  <affiliation ref="#struct-300093"/>
                </author>
              </analytic>
              <monogr>
                <imprint/>
              </monogr>
              <idno type="arxiv">2509.04939</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.bibs">Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]</classCode>
              <classCode scheme="halDomain" n="sdv.bbm.bm">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology</classCode>
              <classCode scheme="halDomain" n="sdv.can">Life Sciences [q-bio]/Cancer</classCode>
              <classCode scheme="halDomain" n="sdv.sp.pharma">Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology</classCode>
              <classCode scheme="halTypology" n="UNDEFINED">Preprints, Working Papers, ...</classCode>
              <classCode scheme="halOldTypology" n="UNDEFINED">Preprints, Working Papers, ...</classCode>
              <classCode scheme="halTreeTypology" n="UNDEFINED">Preprints, Working Papers, ...</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>&lt;div&gt;Background&lt;p&gt;Many advanced cancer patients experience progression under immune-checkpoint inhibitors (ICIs). Circulating cell-free DNA (cfDNA) size profiles offer a promising noninvasive multi-cancer approach to monitor and predict immunotherapy response.&lt;/p&gt;&lt;/div&gt; &lt;div&gt;Methods&lt;p&gt;In the SChISM (Size CfDNA Immunotherapy Signature Monitoring) study (NCT05083494), pre-treatment plasmatic cfDNA size profiles from 126 ICI-treated advanced carcinomas were quantified using the BIABooster device. Fragmentomederived variables (concentration, peaks' position, and fragment size ranges) at baseline were analyzed for associations with early progression (EP, progression at first imaging) and progression-free survival (PFS), using logistic and Cox regression models. Bootstrap analysis validated robustness. Additional analyses were performed in homogeneous subpopulations: first-line lung cancer patients (n = 60) and head-andneck patients treated with Nivolumab (n = 25).&lt;/p&gt;&lt;/div&gt; &lt;div&gt;Results&lt;p&gt;Higher cfDNA concentration and high quantities of short fragments (111-240 base pairs (bp)) were associated with poor response, unlike long fragments (&amp;gt; 300 bp). The proportion of fragments longer than 1650 bp demonstrated highest discriminatory power (AUC = 0.73, C-index = 0.69). It was significantly associated with non-EP (odds ratio = 0.39 [95% CI: 0.25-0.62]) and longer PFS (hazard ratio: 0.54 [95% CI: 0.42-0.68]). These associations remained significant when adjusted for confounders (age, sex, Eastern Cooperative Oncology Group performance status, tumor type, and neutrophil-to-lymphocyte ratio) and across both subpopulations. Bootstrap analysis confirmed robustness with mean accuracy of 70.1 ± 4.17% and positive predictive value of 55.6 ± 7.37%, in test sets.&lt;/p&gt;&lt;/div&gt; &lt;div&gt;Conclusion&lt;p&gt;cfDNA size profiles significantly predicted ICI response and anticipate relapse, outperforming the routinely used marker programmed death-ligand 1 immunohistochemistry and reflecting enhanced immune system activation.&lt;/p&gt;&lt;p&gt;Trial registration: (NCT05083494), date of registration: 2021-10-19.&lt;/p&gt;&lt;/div&gt;</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="researchteam" xml:id="struct-1071285" status="VALID">
          <idno type="RNSR">202124080M</idno>
          <idno type="ROR">https://ror.org/02c7vb662</idno>
          <orgName>Méthodes computationnelles pour la prise en charge thérapeutique en oncologie : Optimisation des stratégies par modélisation mécaniste et statistique</orgName>
          <orgName type="acronym">COMPO</orgName>
          <date type="start">2021-05-01</date>
          <date type="end">2027-12-31</date>
          <desc>
            <address>
              <addrLine>Inria Sophia Antipolis Méditerranée2004 Route des Lucioles06902 Valbonne</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-34586" type="direct"/>
            <relation active="#struct-300009" type="indirect"/>
            <relation active="#struct-179570" type="direct"/>
            <relation name="UM105" active="#struct-198056" type="indirect"/>
            <relation name="UMR7258" active="#struct-301325" type="indirect"/>
            <relation active="#struct-301051" type="indirect"/>
            <relation name="U1068" active="#struct-303623" type="indirect"/>
            <relation name="UMR7258" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-1525607" status="VALID">
          <orgName>ID Solutions Oncology</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.id-solutions.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300073" status="VALID">
          <idno type="ROR">https://ror.org/002cp4060</idno>
          <orgName>Assistance Publique - Hôpitaux de Marseille</orgName>
          <orgName type="acronym">APHM</orgName>
          <desc>
            <address>
              <addrLine>Direction générale AP-HM80, rue Brochier13 354 Marseille Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300093" status="VALID">
          <idno type="ISNI">0000 0001 0404 1115 </idno>
          <idno type="ROR">https://ror.org/05jrr4320</idno>
          <orgName>Hôpital de la Timone [CHU - APHM]</orgName>
          <orgName type="acronym">TIMONE</orgName>
          <date type="start">1974-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/nos-hopitaux/hopital-de-la-timone</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-573134" status="VALID">
          <orgName>Adelis Technologies</orgName>
          <desc>
            <address>
              <addrLine>478 Rue de la Découverte, 31670 Labège, France</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-34586" status="VALID">
          <idno type="RNSR">198318250R</idno>
          <idno type="ROR">https://ror.org/01nzkaw91</idno>
          <orgName>Centre Inria d'Université Côte d'Azur</orgName>
          <desc>
            <address>
              <addrLine>2004 route des Lucioles BP 93 06902 Sophia Antipolis</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inria.fr/centre/sophia/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300009" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300009" status="VALID">
          <idno type="ROR">https://ror.org/02kvxyf05</idno>
          <orgName>Institut National de Recherche en Informatique et en Automatique</orgName>
          <orgName type="acronym">Inria</orgName>
          <desc>
            <address>
              <addrLine>Domaine de VoluceauRocquencourt - BP 10578153 Le Chesnay Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inria.fr/en/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-179570" status="VALID">
          <idno type="RNSR">201220152G</idno>
          <idno type="ROR">0494jpz02</idno>
          <orgName>Centre de Recherche en Cancérologie de Marseille</orgName>
          <orgName type="acronym">CRCM</orgName>
          <date type="start">2012</date>
          <desc>
            <address>
              <addrLine>27 bd Leï Roure, BP 30005913273 Marseille Cedex 09</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://crcm.marseille.inserm.fr/spip.php?article314</ref>
          </desc>
          <listRelation>
            <relation name="UM105" active="#struct-198056" type="direct"/>
            <relation name="UMR7258" active="#struct-301325" type="direct"/>
            <relation active="#struct-301051" type="indirect"/>
            <relation name="U1068" active="#struct-303623" type="direct"/>
            <relation name="UMR7258" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-198056" status="VALID">
          <idno type="IdRef">15863621X</idno>
          <idno type="ISNI">0000 0001 2176 4817</idno>
          <idno type="ROR">https://ror.org/035xkbk20</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301325" status="VALID">
          <idno type="ROR">https://ror.org/04s3t1g37</idno>
          <orgName>Institut Paoli-Calmettes</orgName>
          <orgName type="acronym">IPC</orgName>
          <desc>
            <address>
              <addrLine>232 Boulevard de Sainte-Marguerite13009 Marseille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.institutpaolicalmettes.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301051" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301051" status="VALID">
          <orgName>Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>