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Journal Articles Science Year : 2023

Demographic history and genetic structure in pre-Hispanic Central Mexico

Maximilian Larena
Rosa Fregel
Jazeps Medina Tretmanis
Fernando Villanea
Andrés Moreno-Estrada
Flora Jay
Emilia Huerta-Sanchez
J. Víctor Moreno-Mayar


Aridoamerica and Mesoamerica are two distinct cultural areas in northern and central Mexico, respectively, that hosted numerous pre-Hispanic civilizations between 2500 BCE and 1521 CE. The division between these regions shifted southward because of severe droughts ~1100 years ago, which allegedly drove a population replacement in central Mexico by Aridoamerican peoples. In this study, we present shotgun genome-wide data from 12 individuals and 27 mitochondrial genomes from eight pre-Hispanic archaeological sites across Mexico, including two at the shifting border of Aridoamerica and Mesoamerica. We find population continuity that spans the climate change episode and a broad preservation of the genetic structure across present-day Mexico for the past 2300 years. Lastly, we identify a contribution to pre-Hispanic populations of northern and central Mexico from two ancient unsampled “ghost” populations.
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Dates and versions

hal-04244008 , version 1 (20-10-2023)




Viridiana Villa-Islas, Alan Izarraras-Gomez, Maximilian Larena, Elizabeth Mejía Perez Campos, Marcela Sandoval-Velasco, et al.. Demographic history and genetic structure in pre-Hispanic Central Mexico. Science, 2023, 380 (6645), ⟨10.1126/science.add6142⟩. ⟨hal-04244008⟩
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