Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium - Inria - Institut national de recherche en sciences et technologies du numérique
Journal Articles Molecular Psychiatry Year : 2022

Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium

Laura van Velzen (1) , Maria Dauvermann (2) , Lejla Colic (3) , Luca Villa (3) , Hannah Savage (1) , Yara Toenders (1) , Alyssa Zhu (4) , Joanna Bright (4) , Adrián Campos (5) , Lauren Salminen (4) , Sonia Ambrogi (6) , Rosa Ayesa-Arriola (7) , Nerisa Banaj (6) , Zeynep Başgöze (8) , Jochen Bauer (9) , Karina Blair (10) , Robert James Blair (10) , Katharina Brosch (11) , Yuqi Cheng (12) , Romain Colle (13) , Colm Connolly (14) , Emmanuelle Corruble (13, 15) , Baptiste Couvy-Duchesne (16, 17) , Christopher Davey (1) , Benedicto Crespo-Facorro (18) , Kathryn Cullen (8) , Udo Dannlowski (9) , Katharina Dohm (9) , Janice Fullerton (19) , Ali Saffet Gonul (20) , Ian Gotlib (21) , Dominik Grotegerd (9) , Tim Hahn (9) , Ben Harrison (1) , Mengxin He (12) , Ian Hickie (22) , Tiffany Ho (22) , Frank Iorfino (22) , Andreas Jansen (11) , Fabrice Jollant (15, 23) , Tilo Kircher (11) , Bonnie Klimes-Dougan (8) , Melissa Klug (9) , Elisabeth Leehr (9) , Elizabeth Lippard (24) , Katie Mclaughlin (25) , Susanne Meinert (9) , Adam Bryant Miller (26) , Philip Mitchell (19) , Benson Mwangi (27) , Igor Nenadić (11) , Amar Ojha (28) , Bronwyn Overs (29) , Fabrizio Piras (6) , Julia-Katharina Pfarr (11) , Kai Ringwald (11) , Gloria Roberts (19) , Georg Romer (9) , Marsal Sanches (27) , Gianfranco Spalletta (6) , Margaret Sheridan (26) , Diana Tordesillas-Gutiérrez (30) , Jair Soares (27) , Frederike Stein (11) , Giana Teresi (21) , Aslihan Uyar-Demir (20) , Nic van der Wee (31) , Steven van der Werff (31) , Robert Vermeiren (31) , Alexandra Winter (9) , Mon-Ju Wu (27) , Tony Yang (32) , Paul Thompson (33) , Miguel Rentería (5) , Neda Jahanshad (33) , Hilary Blumberg (3) , Anne-Laura van Harmelen (2) , Laura van Velzen (1) , Nic van der Wee (31) , Steven van der Werff (31) , Anne-Laura van Harmelen (2) , Lianne Schmaal (1)
1 University of Melbourne
2 CAM - University of Cambridge [UK]
3 YSM - Yale School of Medicine [New Haven, Connecticut]
4 USC - University of Southern California
5 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
6 Fondazione Santa Lucia [IRCCS]
7 UC / UniCan - Universidad de Cantabria [Santander] = University of Cantabria [Spain] = Université de Cantabrie [Espagne]
8 University of Minnesota Medical School
9 WWU - Westfälische Wilhelms-Universität Münster = University of Münster
10 Boys Town National Research Hospital [Omaha]
11 Philipps Universität Marburg = Philipps University of Marburg
12 KMU - Kunming Medical University
13 Université Paris-Saclay
14 FSU - Florida State University [Tallahassee]
15 CESP - Centre de recherche en épidémiologie et santé des populations
16 ARAMIS - Algorithms, models and methods for images and signals of the human brain = Algorithmes, modèles et méthodes pour les images et les signaux du cerveau humain [ICM Paris]
17 Institute for Molecular Bioscience
18 Universidad de Sevilla = University of Seville
19 University of New South Wales [Kensington]
20 Ege university
21 Stanford University
22 The University of Sydney
23 IPNP - U1266 Inserm - Institut de psychiatrie et neurosciences de Paris
24 University of Texas at Austin [Austin]
25 Harvard University
26 UNC - University of North Carolina [Chapel Hill]
27 University of Texas Health Science Center
28 UPMC - University of Pittsburgh Medical Center [Pittsburgh, PA, États-Unis]
29 NeuRA - Neuroscience Research Australia
30 Hospital Universitario Marqués de Valdecilla [Santander]
31 LUMC - Leiden University Medical Center
32 UC San Francisco - University of California [San Francisco]
33 Keck School of Medicine [Los Angeles]
Laura van Velzen
Maria Dauvermann
Yara Toenders
Adrián Campos
Sonia Ambrogi
Zeynep Başgöze
Colm Connolly
Christopher Davey
Kathryn Cullen
Ali Saffet Gonul
Ian Gotlib
  • Function : Author
Mengxin He
Ian Hickie
Tiffany Ho
Bronwyn Overs
Fabrizio Piras
Gianfranco Spalletta
Jair Soares
Giana Teresi
  • Function : Author
Aslihan Uyar-Demir
Mon-Ju Wu
Miguel Rentería

Abstract

Abstract Identifying brain alterations associated with suicidal thoughts and behaviors (STBs) in young people is critical to understanding their development and improving early intervention and prevention. The ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium analyzed neuroimaging data harmonized across sites to examine brain morphology associated with STBs in youth. We performed analyses in three separate stages, in samples ranging from most to least homogeneous in terms of suicide assessment instrument and mental disorder. First, in a sample of 577 young people with mood disorders, in which STBs were assessed with the Columbia Suicide Severity Rating Scale (C-SSRS). Second, in a sample of young people with mood disorders, in which STB were assessed using different instruments, MRI metrics were compared among healthy controls without STBs (HC; N = 519), clinical controls with a mood disorder but without STBs (CC; N = 246) and young people with current suicidal ideation ( N = 223). In separate analyses, MRI metrics were compared among HCs ( N = 253), CCs ( N = 217), and suicide attempters ( N = 64). Third, in a larger transdiagnostic sample with various assessment instruments (HC = 606; CC = 419; Ideation = 289; HC = 253; CC = 432; Attempt=91). In the homogeneous C-SSRS sample, surface area of the frontal pole was lower in young people with mood disorders and a history of actual suicide attempts ( N = 163) than those without a lifetime suicide attempt ( N = 323; FDR- p = 0.035, Cohen’s d = 0.34). No associations with suicidal ideation were found. When examining more heterogeneous samples, we did not observe significant associations. Lower frontal pole surface area may represent a vulnerability for a (non-interrupted and non-aborted) suicide attempt; however, more research is needed to understand the nature of its relationship to suicide risk.

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Neuroscience
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hal-03918860 , version 1 (06-06-2023)

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Laura van Velzen, Maria Dauvermann, Lejla Colic, Luca Villa, Hannah Savage, et al.. Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium. Molecular Psychiatry, 2022, 27 (11), pp.4550-4560. ⟨10.1038/s41380-022-01734-0⟩. ⟨hal-03918860⟩
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