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Article Dans Une Revue Journal of Magnetic Resonance Imaging Année : 2022

Influence of different measurement methods of arterial input function on quantitative dynamic contrast‐enhanced MRI parameters in head and neck cancer

Résumé

Background Head and neck cancer (HNC) is the sixth most prevalent cancer worldwide. Dynamic contrast-enhanced MRI (DCE-MRI) helps in diagnosis and prognosis. Quantitative DCE-MRI requires an arterial input function (AIF), which affects the values of pharmacokinetic parameters (PKP). Purpose To evaluate influence of four individual AIF measurement methods on quantitative DCE-MRI parameters values (Ktrans, ve, kep, and vp), for HNC and muscle. Study Type Prospective. Population A total of 34 HNC patients (23 males, 11 females, age range 24–91) Field Strength/Sequence A 3 T; 3D SPGR gradient echo sequence with partial saturation of inflowing spins.Assessment Four AIF methods were applied: automatic AIF (AIFa) with up to 50 voxels selected from the whole FOV, manual AIF (AIFm) with four voxels selected from the internal carotid artery, both conditions without (Mc−) or with (Mc+) motion correction. Comparison endpoints were peak AIF values, PKP values in tumor and muscle, and tumor/muscle PKP ratios. Statistical Tests Nonparametric Friedman test for multiple comparisons. Nonparametric Wilcoxon test, without and with Benjamini Hochberg correction, for pairwise comparison of AIF peak values and PKP values for tumor, muscle and tumor/muscle ratio, P value ≤ 0.05 was considered statistically significant. Results Peak AIF values differed significantly for all AIF methods, with mean AIFmMc+ peaks being up to 66.4% higher than those for AIFaMc+. Almost all PKP values were significantly higher for AIFa in both, tumor and muscle, up to 76% for mean Ktrans values. Motion correction effect was smaller. Considering tumor/muscle parameter ratios, most differences were not significant (0.068 ≤ Wilcoxon P value ≤ 0.8). Data Conclusion We observed important differences in PKP values when using either AIFa or AIFm, consequently choice of a standardized AIF method is mandatory for DCE-MRI on HNC. From the study findings, AIFm and inflow compensation are recommended. The use of the tumor/muscle PKP ratio should be of interest for multicenter studies
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Dates et versions

hal-03875359 , version 1 (28-11-2022)

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Wanxin Dong, Andreas Volk, Meriem Djaroum, Charly Girot, Corinne Balleyguier, et al.. Influence of different measurement methods of arterial input function on quantitative dynamic contrast‐enhanced MRI parameters in head and neck cancer. Journal of Magnetic Resonance Imaging, 2022, 2022, ⟨10.1002/jmri.28486⟩. ⟨hal-03875359⟩
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