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Article Dans Une Revue Applied Mathematics Letters Année : 2022

Virus replication and competition in a cell culture: Application to the SARS-CoV-2 variants

Résumé

Viral replication in a cell culture is described by a delay reaction-diffusion system. It is shown that infection spreads in cell culture as a reaction-diffusion wave, for which the speed of propagation and viral load can be determined both analytically and numerically. Competition of two virus variants in the same cell culture is studied, and it is shown that the variant with larger individual wave speed outcompetes another one, and eliminates it. This approach is applied to the Delta and Omicron variants of the SARS-CoV-2 infection in the cultures of human epithelial and lung cells, allowing characterization of infectivity and virulence of each variant, and their comparison.

Dates et versions

hal-03840306 , version 1 (05-11-2022)

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L Ait Mahiout, Anastasia Mozokhina, A Tokarev, V Volpert. Virus replication and competition in a cell culture: Application to the SARS-CoV-2 variants. Applied Mathematics Letters, 2022, 133, ⟨10.1016/j.aml.2022.108217⟩. ⟨hal-03840306⟩
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