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Journal Articles European Journal of Clinical Microbiology and Infectious Diseases Year : 2022

Impact of medical and pharmaceutical interventions on anti-infective prescriptions: an observational study

Abstract

Appropriate prescribing of anti-infectives is a public health challenge. In our hospital, clinical microbiologists (clinical microbiology mobile unit, UMMc) and clinical pharmacists (clinical pharmacy, PHAc) carry out interventions on anti-infective prescriptions to improve practices. Our main objective was to evaluate the acceptance of UMMc and PHAc interventions on anti-infective prescriptions by quantifying the rate of prescription change 24 h after intervention. The secondary objective was to characterize the type of intervention and associate the rate of change for each. All prescriptions are computerized, and interventions traced via DxCare® software, which feeds a local data warehouse (HEGP-CDW). This descriptive, retrospective, single-center, uncontrolled study was conducted from January 2015 to December 2018. The data were extracted over this period from the data warehouse and analyzed using R software. UMMc interventions were accepted 72.2% of the time and PHA interventions 87.3%. The types of interventions found were mostly dose adjustments (61.1% for the UMMc and 54.2% for the PHAc) and proposals to change or stop a drug. Interventions have an impact on anti-infective prescriptions and are generally followed by clinicians. For the category “discontinuation of a molecule”, almost half of the advice from the UMMc was refused. The collaboration between the UMMc and PHAc should be reinforced to improve acceptance.
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Dates and versions

hal-03794006 , version 1 (02-10-2022)

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Emma Pinet, Pierre Sabatier, Marie-Paule Fernandez-Gerlinger, Anne-Sophie Jannot, Jean-Luc Mainardi, et al.. Impact of medical and pharmaceutical interventions on anti-infective prescriptions: an observational study. European Journal of Clinical Microbiology and Infectious Diseases, 2022, 41 (7), pp.1077-1086. ⟨10.1007/s10096-022-04465-w⟩. ⟨hal-03794006⟩
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