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Article Dans Une Revue Neurobiology of Aging Année : 2017

The frequency and influence of dementia risk factors in prodromal Alzheimer's disease

1 Maastricht University [Maastricht]
2 Universität Heidelberg [Heidelberg] = Heidelberg University
3 FAU - Friedrich-Alexander Universität Erlangen-Nürnberg = University of Erlangen-Nuremberg
4 Georg-August-University = Georg-August-Universität Göttingen
5 Universität Bonn = University of Bonn
6 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
7 UA - University of Antwerp
8 VUB - Vrije Universiteit Brussel
9 Aristotle University of Thessaloniki
10 Karolinska Institutet [Stockholm]
11 Copenhagen University Hospital
12 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
13 Hospital de la Santa Creu i Sant Pau
14 UNIGE - Université de Genève = University of Geneva
15 IRCCS - Centro San Giovanni di Dio, Fatebenefratelli, Brescia
16 UniGe - Università degli studi di Genova = University of Genoa
17 University of Cologne
18 INS - Institut de Neurosciences des Systèmes
19 TIMONE - Hôpital de la Timone [CHU - APHM]
20 VU University Medical Center [Amsterdam]
21 CHU-Liège - Centre Hospitalier Universitaire de Liège
22 Université de Liège
23 Centro Hospitalar e Universitário [Coimbra]
24 Université de Lisbonne
25 GU - Göteborgs Universitet = University of Gothenburg
26 F. Hoffmann-La Roche [Basel]
27 Roche Products Ltd
28 Janssen Research & Development
29 Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield
30 Skane University Hospital [Lund]
31 CHU Pitié-Salpêtrière [AP-HP]
32 ICM - Institut du Cerveau = Paris Brain Institute
33 University of Eastern Finland
Yvonne Freund-Levi
Alberto Lleó
Daniel Alcolea
Hilkka Soininen
Pieter Jelle Visser

Résumé

We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Cox-regression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hypercholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD.

Domaines

Neurosciences

Dates et versions

hal-03623839 , version 1 (29-03-2022)

Identifiants

Citer

Isabelle Bos, Stephanie Vos, Lutz Frölich, Johannes Kornhuber, Jens Wiltfang, et al.. The frequency and influence of dementia risk factors in prodromal Alzheimer's disease. Neurobiology of Aging, 2017, 56, pp.33-40. ⟨10.1016/j.neurobiolaging.2017.03.034⟩. ⟨hal-03623839⟩
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