A prospective behavioral and imaging study exploring the impact on long-term memory of radiotherapy delivered for a brain tumor in childhood and adolescence
Abstract
Posterior fossa tumors represent two thirds of brain tumors in children. Although progress in treatment has improved survival rates over the past few years, long-term memory impairments in survivors are frequent and have an impact on academic achievement. The hippocampi, cerebellum and cerebellar-cortical networks play a role in several memory systems. They are affected not only by the location of the tumor itself and its surgical removal, but also by the supratentorial effects of complementary treatments, particularly radiotherapy. The IMPALA study will investigate the impact of irradiation doses on brain structures involved in memory, especially the hippocampi and cerebellum.
Keywords
CMS
Children's Memory Scale
DFA
discriminating factor analysis
DTI
diffusion tensor imaging
IQ
intellectual quotient
MEM-III
Wechsler Memory Scale
Magnetic resonance imaging
Memory
NTCP
normal tissue complication probability
PFT
posterior fossa tumor
Posterior fossa brain tumor
Radiotherapy
SRTT
serial reaction time task
Spectroscopy
TCP
tumor control probability
WAIS
Wechsler Adult Intelligence Scale
WISC
Wechsler Intelligence Scale for Children
pCASL
pseudocontinuous arterial spin labeling
rs-fMRI
resting-state functional magnetic resonance imaging
3DT1
T1-weighted imaging
Domains
Cancer
Origin : Publisher files allowed on an open archive
Licence : CC BY NC ND - Attribution - NonCommercial - NoDerivatives
Licence : CC BY NC ND - Attribution - NonCommercial - NoDerivatives